Epidemiology Mesothelioma

Epidemiology Mesothelioma

Epidemiologically, mesothelioma is one of the malignancies that have a low prevalence in the world. This disease is generally only related to its main risk factor, namely exposure to asbestos from occupational or environmental. Individuals with no history of asbestos exposure have a very low incidence rate, which is less than 1 case per 1 million inhabitants.

In Indonesia, mesothelioma is also a malignancy that is very rarely found. The incidence rate is only 0.1 per 100,000 population at risk of asbestos exposure.

Mesothelioma Health Education And Promotion

Education and health promotion that can be given to patients who are at risk of experiencing mesothelioma is to stop smoking. Smoking will increase the risk of lung cancer and mesothelioma. Currently, products that can provide exposure to asbestos have also been restricted.

Patient Education

Patients who have been diagnosed with mesothelioma should be educated about the possible causes of the disease, the treatment that needs to be undertaken, and the complications that may arise from treatment. In addition, the doctor also needs to explain the prognosis to the patient and family. Patients are also advised to avoid cigarettes.

Pathophysiology Of Mesothelioma

The pathophysiology of mesothelioma is closely related to chronic inflammation. A carcinogenic inflammatory agent that has been known to cause mesothelioma is asbestos. There are two major groups of asbestos, serpentine asbestos, and amphibole asbestos. Exposure to amphiboles-type asbestos fibers has a higher risk of carcinogenesis than serpentine types. Amphibole type fibers are longer than serpentine type.

In addition to asbestos, erionite minerals, infections (such as tuberculosis infection or simian V40 virus), and radiation exposure can also induce inflammation that forms a chronic repetitive cycle in mesothelial cells.

Source

1. Mott FE. Mesothelioma: a review. Ochsner J. 2012;12(1):70-79.

2. Marinaccio A, Corfiati M, Binazzi A, et al. The epidemiology of malignant mesothelioma in women: gender differences and modalities of asbestos exposure. Occupy Environ Med. 2018 Apr;75 (4):254-262.

3. Hiriart E, Deepa R, Wessels A. Mesothelium and Malignant Mesothelioma. J Dev Biol. 2019;7(2):7. DOI: 10.3390/jdb7020007

5. Carbone M, Ly BH, Dodson RF, et al. Malignant mesothelioma: facts, myths, and hypotheses. J Cell Physiol. 2012 Jan;227 (1): 44-58. DOI: 10.1002/jcp.22724.

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